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What is N.O.X and what are the Benefits of Nitric Oxide

Writer: Healthy FoxHealthy Fox
Feb 45 min read

Updated: Feb 8

“I include this product in my daily routine especially before a workout. I first started taking it due to the research saying that increasing your natural Nitric Oxide (NO) levels prevented long-term plaque breakup which lowers your chance of Heart Disease and Stroke. What took me by surprise was my capacity to workout and strength in the gym was largely increased. The increased blood flow from NO I felt in 15 minutes, my hands, face and feet warmed up, my brain fog disappeared and immediately got excited to exercise. This product checks all the boxes for a pre workout, preventing muscle soreness and encouraging your body to build muscle. Although this product works for both men and women, the cherry on top I’ve heard from other guys is the increased blood flow ‘outside the gym’.”  Bryce





N.O.X™Comprehensive Support for Optimized Nitric Oxide Production

N.O.X™ is a comprehensive formula designed to optimize nitric oxide (NO) levels in the body. Provided in a delicious berry-flavored powder, it ensures convenient dosing and supports patient compliance.

N.O.X™ may be helpful for:

  • Increasing the body’s production of NO

  • Extending the half-life of NO in the body

  • Protecting NO from harmful peroxynitrite formation

  • Enhancing ATP production



Key Ingredients and Benefits

Arginine and Citrulline:Arginine is a vital substrate for NO synthesis, promoting the relaxation of endothelial cells and reducing platelet aggregation and oxidative stress.¹ However, high arginase activity in the small intestine can degrade dietary arginine, reducing its systemic bioavailability.¹

Citrulline complements arginine by serving as its precursor, bypassing intestinal metabolism and inhibiting tissue arginase.² It raises plasma arginine levels more effectively than arginine itself, acting as a "time-released arginine."³ Studies have shown that citrulline supplementation improves NO production, with benefits such as enhanced erectile function.³,⁴

N.O.X™ combines citrulline with glutathione, which enhances NO synthesis and supports recovery after intense physical activity by promoting muscle protein synthesis.⁶



Folate (as 5-MTHF):Folate, in its bioactive form 5-MTHF, supports the activity of nitric oxide synthase (NOS) by serving as a precursor to tetrahydrobiopterin (BH4).⁷ BH4 is a crucial cofactor for NOS, preventing the formation of superoxide radicals that can occur when BH4 is deficient.⁸,⁹ Adequate folate levels are essential for maintaining NO synthesis and proper homocysteine metabolism.¹⁰


Grape (Vitis vinifera) and Apple (Malus pumila) Extracts:N.O.X™ includes a proprietary blend of polyphenols from grapes and apples, known for their antioxidant and vasodilating properties. These polyphenols enhance eNOS activity, increasing NO production and improving vascular health.¹¹⁻¹⁴ Vitamin C, included for its collagen-building and vasoprotective properties, works synergistically with these polyphenols to maintain capillary integrity.¹⁵⁻¹⁶

Phloretin, a key apple polyphenol, reduces inflammatory markers and platelet aggregation, contributing to cardiovascular protection.¹⁷,¹⁸


Taurine:This sulfonic acid derivative supports cardiovascular health through anti-arrhythmic and hypotensive properties.¹⁹ Taurine enhances NO production by increasing eNOS expression and plasma arginine levels while reducing synthesis of the NOS inhibitor ADMA.²² Studies show taurine alleviates hypertension, reduces arterial stiffness, and combats vascular inflammation.²¹


Chelated Creatine/Magnesium Complex:N.O.X™ features a creatine-magnesium chelate that supports ATP production, muscle performance, and cardiovascular health. Magnesium facilitates the anabolic activity of creatine by stabilizing it, preventing conversion to creatinine.²³⁻²⁷ This combination enhances muscle strength, growth, and recovery, benefiting athletic performance and endurance.²⁸⁻³⁰


Benefits of N.O.X™*

Cardiovascular Health:

  • Enhances endothelial function by increasing NO production

  • Promotes blood vessel relaxation and supports healthy blood pressure

  • Supports sexual health by maintaining erectile function


Athletic Performance:

  • Increases blood flow to muscles and boosts ATP production

  • Improves exercise intensity and duration

  • Antioxidants aid in recovery from intense physical activity


Here are the references formatted according to your preferences:

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  2. Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev. 2006 Fall-Winter;24(3-4):275-90.

  3. Cormio L, De Siati M, Lorusso F, Selvaggio O, Mirabella L, Sanguedolce F, Carrieri G. Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction. Urology. 2011 Jan;77(1):119-22.

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