“There’s a reason this product is in nearly every Health Journey! This B12 is so good for the longevity and overall health of every person. This is unlike other products on the market with uniquely 3 Types of B12 (Hydroxy, Adenosyl, Methyl) alongside the neurological powerhouse Quatrefolic (5-MTHF). We knew we had to include this product for the very much needed methylation and overall brain health benefits. They also are oddly addicting lozenges!” Bryce & Dr. Michelle
B.1.2™ contains a synergistic combination of three bioavailable forms of vitamin B12 as methylcobalamin (Me‑Cbl), hydroxycobalamin (OH‑Cbl), and adenosylcobalamin (Ado‑Cbl) with a patented active form of folate as [6S]‑5‑methyltetrahydrofolate ([6S]5‑MTHF). Vitamin B12, also known as cobalamin (Cbl), is a water‑soluble micronutrient essential for cellular repair and function, energy metabolism, and neurological health. It is not produced by humans and must be obtained from dietary sources or supplementation. The forms of vitamin B12 found in B.1.2™ (i.e., Me‑Cbl, OH‑Cbl, and Ado‑Cbl) are naturally occurring forms found in human physiology and dietary sources and may be preferable to cyanocobalamin (CN‑Cbl), the synthetic form of vitamin B12 found in most supplements and fortified foods.¹
There are more than 20 genes involved in the absorption, transport, modification, and utilization of cobalamin from dietary sources.² Supplementation with these bioavailable forms of vitamin B12 may benefit individuals with various genetic polymorphisms affecting B12 metabolism and related pathways.¹
Certain groups are at risk of vitamin B12 deficiency, including older adults, those with pernicious anemia, vegetarians and vegans, certain pregnant and lactating individuals, and those with gastrointestinal conditions (e.g., celiac disease, Crohn’s disease) or who have undergone bariatric surgery. These individuals may benefit from supplementation with cobalamin to bypass intrinsic factor deficiencies through potential passive diffusion.¹,³,⁴
Folate, or vitamin B9, works synergistically with vitamin B12 in many biochemical reactions. It is critical for DNA health and the optimal function of every system in the body.⁵ The form of folate in B.1.2™, [6S]5‑MTHF, is a bioidentical form ideal for supplementation compared with folic acid, the synthetic form found in most dietary supplements and fortified foods.⁶
Formula Highlights
Synergistic blend of three bioactive forms of vitamin B12 (methylcobalamin, hydroxycobalamin, and adenosylcobalamin)
3,000 mcg of vitamin B12 to support cellular and neurological health
680 mcg DFE of a patented bioactive form of folate (as Quatrefolic® [6S]‑5‑MTHF) to support homocysteine metabolism and methylation
Great‑tasting, orange-flavored lozenge
Lozenge delivery for superior nutrient absorption and bioavailability
Ingredient Highlights
Vitamin B12 Benefits
Promotes neurological health
Supports healthy cellular energy metabolism
Enhances cellular repair and function
Facilitates healthy detoxification pathways
Supports cognition and mood
Aids healthy fetal development
Maintains healthy methylation and homocysteine levels
Folate Benefits
Folate supports:
DNA synthesis and repair
Healthy homocysteine levels
Fetal neural tube development
Amino acid metabolism
Vitamin B12 is predominantly found in animal foods such as meat, fish, poultry, dairy, and eggs. B12 is unique as the only water‑soluble vitamin stored in appreciable amounts in the body, and deficiencies may take years to manifest.⁷
References
1. Paul C, Brady DM. Comparative bioavailability and utilization of particular forms of B12 supplements with potential to mitigate B12‑related genetic polymorphisms. Integr Med (Encinitas). 2017;16(1):42‑49. https://pubmed.ncbi.nlm.nih.gov/28223907/
2. Froese DS, Fowler B, Baumgartner MR. Vitamin B12, folate, and the methionine remethylation cycle‑biochemistry, pathways, and regulation. J Inherit Metab Dis. 2019;42(4):673‑685. doi:10.1002/jimd.12009
3. Langan RC, Goodbred AJ. Vitamin B12 deficiency: recognition and management. Am Fam Physician. 2017;96(6):384‑389. https://www.aafp.org/afp/2017/0915/p384.html
4. Cavalcoli F, Zilli A, Conte D, Massironi S. Micronutrient deficiencies in patients with chronic atrophic autoimmune gastritis: a review. World J Gastroenterol. 2017;23(4):563‑572. doi:10.3748/wjg.v23.i4.563
5. Folate Fact Sheet for Health Professionals. Dietary Supplements Fact Sheets, Health Information, Office of Dietary Supplements, National Institutes of Health. U.S. Department of Health & Human Services. Updated March 29, 2021. Accessed October 08, 2021. https://ods.od.nih.gov/factsheets/Folate‑HealthProfessional/
6. Miraglia N, Agostinetto M, Bianchi D, Valoti E. Enhanced oral bioavailability of a novel folate salt: comparison with folic acid and a calcium folate salt in a pharmacokinetic study in rats. Minerva Ginecol. 2016;68(2):99‑105. https://pubmed.ncbi.nlm.nih.gov/27008238/
7. Vitamin B12 Fact Sheet for Health Professionals. Dietary Supplements Fact Sheets, Health Information, Office of Dietary Supplements, National Institutes of Health. U.S. Department of Health & Human Services. Updated April 6, 2021. Accessed October 08, 2021. https://ods.od.nih.gov/factsheets/VitaminB12‑HealthProfessional/
8. Didangelos T, Karlafti E, Kotzakioulafi E, et al. Vitamin B12 supplementation in diabetic neuropathy: a 1‑year, randomized, double‑blind, placebo‑controlled trial. Nutrients. 2021;13(2):395. doi:10.3390/nu13020395
9. Satapathy S, Bandyopadhyay D, Patro BK, Khan S, Naik S. Folic acid and vitamin B12 supplementation in subjects with type 2 diabetes mellitus: a multi‑arm randomized controlled clinical trial. Complement Ther Med. 2020;53:102526. doi:10.1016/j.ctim.2020.102526
10. Zhu X, Xiang S, Feng X, et al. Impact of cyanocobalamin and methylcobalamin on inflammatory bowel disease and the intestinal microbiota composition. J Agric Food Chem. 2019;67(3):916‑926. doi:10.1021/acs.jafc.8b05730
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